8/31/2023 0 Comments Importance of palindromic sequencereverse palindrome, occur in DNA sequences. From the study of restriction endonucleases in the 60's and the early 70's, it became clear that a certain type of palindrome, i.e. With the progress of molecular biology in the 20th century, a new level of symmetry was discovered in nature. Since then, many other famous palindromic sentences have been constructed in different languages. Note that the word "tenet" is a palindrome itself. The Sator Square contains probably the oldest known palindrome, which shows the Latin sentence "SATOR AREPO TENET OPERA ROTAS". "palindromes") goes back to at least 20 centuries ago. Human beings have always been attracted to symmetrical properties of natural phenomena, and their interest is reflected in art.Ĭreation of symmetrical sentences (i.e. Symmetry of shapes is something that is found everywhere in nature. Finally, we demonstrated that the two sides of a palindrome generally do not show significant structural similarities. It is shown that palindromes may have a great propensity to form α-helical structures. Furthermore, to answer the last two questions, the structural characteristics of palindromes were studied. However, in many cases we failed to find any symmetry in the conserved regions of corresponding Blocks. In fact, we found several palindromes that overlap with conserved protein Blocks of different functions. Nevertheless, this does not rule out the possibility of finding palindromes which play some roles in protein structure and function. Therefore, one can say that palindromes occur frequently in low complexity protein segments, without necessarily having a defined function or forming a special structure. What is the role of sequence complexity in the evolution of palindromic sequences in proteins? (2) Do palindromes coincide with conserved protein sequences? If yes, what are the functions of these conserved segments? (3) In case of conserved palindromes, is it always the case that the whole conserved pattern is also symmetrical? (4) Do palindromic protein sequences form regular secondary structures? (5) Does sequence similarity of the two "sides" of a palindrome imply structural similarity? For the first question, we showed that the complexity of palindromic peptides is significantly lower than randomly generated palindromes. sequences with extreme amino acid usage bias). (1) It is known that there is a large chance of finding a palindrome in low complexity sequences (i.e. Several questions are addressed in this work. In this work, we tried to revisit this relatively neglected phenomenon.
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